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CJC-1295 vs Ipamorelin

Two unapproved growth-hormone secretagogues that are often sold as a pair, compared on mechanism, human evidence, status and risks.

✓ Written by Derek Giordano, Founder & Editor · Last reviewed October 8, 2026 · Medical disclaimer
CJC-1295
GHRH analog
VS
Ipamorelin
Ghrelin-receptor GH secretagogue
FactorCJC-1295Ipamorelin
MechanismMimics growth-hormone-releasing hormone (GHRH)Activates the ghrelin (GH secretagogue) receptor
Human evidenceA 2006 study in healthy adults showed raised GH and IGF-1 levels; no outcome trialsReached a trial for postoperative ileus and was not developed further; no outcome trials for body composition
FDA approvalNot approvedNot approved
SportProhibited (WADA)Prohibited (WADA)
Main concernsWater retention, joint pain, reduced insulin sensitivity; unknown long-term effects of raised IGF-1Effects on blood sugar and fluid balance; unknown long-term safety
Established human doseNone for the uses it is marketed forNone for the uses it is marketed for

⚖️ The verdict

Raising growth hormone or IGF-1 levels in a blood test is not the same as better body composition, sleep or longevity, and neither compound has trials showing those outcomes. The popular combination of the two has not been tested in controlled human studies. Both are banned in sport and unapproved, and products sold online carry unknown purity.

Why there are no doses on this page

Neither compound has an established human dose. Figures in seller protocols are extrapolated from animal studies, so nnng.com does not repeat them. Full profiles: CJC-1295 · Ipamorelin.

Frequently asked questions

Why are CJC-1295 and ipamorelin sold together?
They act on two different receptors in the growth hormone pathway, so sellers market them as complementary. The combination has not been tested in controlled human trials.
Does CJC-1295 build muscle?
It raised growth hormone and IGF-1 levels in a 2006 study, but no trial has shown muscle or body-composition benefits.
Are CJC-1295 and ipamorelin legal?
Neither is FDA-approved, and both are prohibited in sport.