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CJC-1295 (No DAC) — Growth Hormone Releasing Hormone Analog

✍️ Reviewed by nnng.com Editorial Team · April 2026 · Medical disclaimer

GHRH analog that stimulates pulsatile GH release — best stacked with Ipamorelin.

📍 Growth Hormone ⏱ 1–3× daily, fasted 💉 SubQ 🔄 Cycle: 3–6 months on, 1 month off ⏳ Half-life: 30 minutes (no DAC version) ❄️ Storage: 30 days refrigerated

📋 What is CJC-1295?

CJC-1295 (no DAC) is a synthetic analog of growth hormone-releasing hormone (GHRH). It stimulates the pituitary gland to release growth hormone in a pulsatile pattern that mimics natural physiological secretion. The 'no DAC' version has a shorter half-life (~30 min) making it preferred for maintaining natural GH pulsatility.

Mechanism: CJC-1295 binds to GHRH receptors on pituitary somatotrophs, amplifying the natural GH pulse. By combining it with a GHRP like Ipamorelin, you activate two independent receptor pathways simultaneously, producing a synergistic and larger GH pulse than either alone.

✅ Key Benefits

Increased GH and IGF-1 levels
Enhanced muscle recovery and growth
Improved body composition (fat loss + lean mass)
Better sleep quality and deep sleep
Anti-aging effects (skin, energy, cognitive clarity)
Improved bone density

🧬 CJC-1295 Reconstitution Calculator

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⚠️ Research use only. Not medical advice. Consult a licensed healthcare provider before using any peptide.

💉 Dosing Reference Table

Goal	Dose	Frequency	Best Time
Standard / anti-aging	100 mcg	2× daily	Morning fasted + before bed
Body recomp / performance	200 mcg	2–3× daily	Morning + post-workout + bed
Beginner / low dose	100 mcg	1× daily	Before bed

CJC-1295 (no DAC) is almost always used stacked with Ipamorelin at a 1:1 ratio (same mcg dose). Inject fasted — food (especially carbs and fat) raises insulin and somatostatin, blunting the GH pulse. Wait at least 2 hours after eating. The before-bed injection takes advantage of the natural deep-sleep GH pulse. Cycle 3–6 months on with 1 month off to prevent desensitization.

🔀 Common Stacks

+ Ipamorelin

The definitive stack — combine equal mcg doses for synergistic GH pulse. The most popular GH secretagogue combination.

+ BPC-157

Adding BPC-157 creates a comprehensive recovery and body composition stack.

❓ Frequently Asked Questions

What's the difference between CJC-1295 with DAC and without DAC?

DAC (Drug Affinity Complex) extends the half-life to 8+ days, allowing once-weekly dosing but at the cost of continuous GH elevation rather than physiological pulses. Most researchers prefer no-DAC for its shorter half-life (30 min) and pulsatile pattern that better mimics natural GH secretion and is thought to be safer long-term.

Why stack with Ipamorelin rather than use CJC-1295 alone?

CJC-1295 and Ipamorelin work on completely different receptor systems — GHRH receptors and ghrelin/GHS receptors respectively. Activating both simultaneously produces a synergistic GH pulse 3–10× larger than either alone. Ipamorelin also suppresses somatostatin (GH inhibitor), removing the brake on GH release.

Will this suppress natural GH production?

Pulsatile GH secretagogues like CJC-1295 (no DAC) + Ipamorelin are thought to maintain natural pituitary function and HPTA health better than direct GH administration. They stimulate, rather than replace, natural GH production. A 1-month break every 3–6 months is recommended to maintain receptor sensitivity.