A synthetic four-amino-acid peptide promoted for anti-aging, based largely on research from one group in Russia.
Epithalon (also spelled epitalon) is a synthetic tetrapeptide (alanine-glutamic acid-aspartic acid-glycine) modeled on epithalamin, an extract of the pineal gland. It is promoted online for longevity, sleep and telomere effects.
Epithalon is not an FDA-approved drug. It was in FDA's 503A Category 2, removed in April 2026, and in July 2026 the Pharmacy Compounding Advisory Committee voted to recommend adding it to the 503A bulks list. That recommendation is non-binding and has not been finalized.
Status reflects public FDA actions and reporting as of October 8, 2026. An advisory committee vote is a recommendation, not an FDA decision, and inclusion on a compounding list is not FDA approval.
Most published research comes from the St. Petersburg group led by Vladimir Khavinson, including cell studies on telomerase and animal lifespan studies. Independent replication and controlled human trials are lacking, so anti-aging claims in people are unproven.
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