The longevity peptide — activates telomerase and may extend telomere length.
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from Epithalamin — a peptide isolated from the pineal gland by the late Russian scientist Vladimir Khavinson. It is one of the most studied anti-aging peptides, with over 100 publications examining its effects on telomere length, cancer prevention, circadian rhythm, and lifespan.
Mechanism: Epithalon is proposed to activate telomerase — the enzyme that elongates telomeres, the protective caps on chromosomes that shorten with each cell division. Shorter telomeres are associated with cellular aging and increased disease risk. Epithalon also normalizes melatonin secretion, restores circadian rhythm, and has antioxidant effects.
| Protocol | Dose | Duration | Frequency |
|---|---|---|---|
| Standard course | 5 mg/day | 10 days | 1–2× per year |
| Higher dose course | 10 mg/day | 10–20 days | 1–2× per year |
| Long course | 5–10 mg/day | 20 days | Once per year |
Epithalon is taken in courses rather than continuously. The most common protocol: 5–10 mg/day SubQ for 10–20 consecutive days, 1–2 times per year. Unlike most peptides, it is not taken daily year-round. Some practitioners prefer IV administration for the longevity courses. Reconstituted Epithalon should be used within 10 days — the tetrapeptide is less stable than longer peptides once mixed.