Naturally occurring copper tripeptide — regenerates skin, hair, and connective tissue.
GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) found in human plasma, saliva, and urine. Its concentration declines dramatically with age (from ~200 ng/mL at 20 to ~80 ng/mL at 60). GHK-Cu regulates over 4,000 human genes and has extensive research supporting its role in wound healing, skin regeneration, and anti-aging.
Mechanism: GHK-Cu stimulates collagen and elastin synthesis, promotes angiogenesis, activates antioxidant pathways, and regulates metalloproteinases (enzymes that break down damaged tissue). It upregulates growth factors (VEGF, FGF, TGF-β) and downregulates inflammatory pathways.
| Application | Dose | Route | Frequency |
|---|---|---|---|
| Systemic anti-aging | 1–2 mg | SubQ | Once daily |
| Wound/scar healing | 1–2 mg | SubQ near site | Once daily |
| Topical (skin) | Apply solution | Topical | 1–2× daily |
| Hair loss | 1 mg | SubQ scalp or systemic | Once daily |
For systemic use: 1–2 mg SubQ once daily. For topical use: reconstitute at 1–2 mg/mL in saline and apply directly to skin. GHK-Cu is one of the few peptides with both solid injectable and topical evidence. Copper excess is unlikely at these doses given the extremely small copper content per dose, but longer cycles should be monitored.