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Ipamorelin — Selective Growth Hormone Secretagogue

✍️ Reviewed by nnng.com Editorial Team · April 2026 · Medical disclaimer

The cleanest GHRP — selective GH release with minimal cortisol or prolactin elevation.

📍 Growth Hormone ⏱ 1–3× daily 💉 SubQ 🔄 Cycle: 3–6 months on, 1 month off ⏳ Half-life: ~2 hours ❄️ Storage: 30 days refrigerated

📋 What is Ipamorelin?

Ipamorelin is a pentapeptide GHRP (Growth Hormone Releasing Peptide) and ghrelin mimetic. It is considered the most selective GHRP available — it stimulates GH release with minimal effect on cortisol, prolactin, or ACTH, making it safer and better tolerated than older GHRPs like GHRP-2 and GHRP-6.

Mechanism: Ipamorelin binds to ghrelin/GHS-R receptors on pituitary somatotrophs and the hypothalamus, triggering GH release. Unlike GHRP-2 and GHRP-6, it does not strongly activate cortisol or prolactin pathways. Combined with CJC-1295, it activates two independent receptor systems for synergistic effect.

✅ Key Benefits

Clean GH release without cortisol/prolactin elevation
Improved sleep quality (especially deep sleep)
Enhanced recovery and reduced soreness
Improved body composition
Anti-aging skin and collagen benefits
Neuroprotective effects

🧬 Ipamorelin Reconstitution Calculator

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⚠️ Research use only. Not medical advice. Consult a licensed healthcare provider before using any peptide.

💉 Dosing Reference Table

Goal	Dose	Frequency	Timing
Anti-aging / general	150–200 mcg	1–2× daily	Before bed
Body recomp	200–300 mcg	2–3× daily	Fasted: morning, post-workout, bed
Beginner / conservative	100 mcg	1× daily	Before bed

Inject fasted — carbs and fat raise insulin and somatostatin which blunt the GH pulse. The most impactful single dose is before sleep, which amplifies the natural deep-sleep GH pulse. Stack with CJC-1295 (no DAC) at the same dose (e.g., 200 mcg Ipamorelin + 200 mcg CJC-1295 per injection).

🔀 Common Stacks

+ CJC-1295 (no DAC)

The definitive stack. Same dose of each, same injection, multiple times daily. Produces synergistic GH pulse.

+ BPC-157

Comprehensive recovery stack combining GH stimulation with direct tissue repair.

❓ Frequently Asked Questions

Why is Ipamorelin preferred over GHRP-2 and GHRP-6?

GHRP-2 and GHRP-6 significantly raise cortisol (the primary stress hormone) and GHRP-6 causes substantial hunger. Ipamorelin is highly selective — it releases GH without meaningful cortisol elevation and causes minimal to no increase in hunger, making it much better tolerated for regular use.

How much GH does Ipamorelin release?

A 200 mcg dose produces a GH pulse roughly equivalent to natural exercise-induced GH secretion. Combined with CJC-1295, the pulse is significantly amplified. This is far below therapeutic HGH doses (typically 1–4 IU/day) but may be sufficient for recovery, anti-aging, and body composition goals with a better safety profile.