The gentle GHRH — stimulates your own pituitary to produce natural GH.
Sermorelin is a synthetic analog of the first 29 amino acids of human growth hormone-releasing hormone (GHRH 1-29). FDA-approved for growth hormone deficiency in children, it is widely used off-label for adult GH optimization and anti-aging. It stimulates the pituitary gland to produce GH naturally, rather than replacing it exogenously.
Mechanism: Sermorelin binds to GHRH receptors on pituitary somatotrophs, stimulating GH synthesis and secretion. Because it works through the pituitary (rather than injecting GH directly), it maintains the pituitary's regulatory feedback mechanisms and produces more physiological GH patterns.
| Age/Goal | Dose | Frequency | Timing |
|---|---|---|---|
| Anti-aging (40–60) | 200–300 mcg | Once daily | Before bed |
| GH optimization | 300–500 mcg | Once daily | Before bed |
| With Ipamorelin stack | 200 mcg | 1–2× daily | Fasted |
Once daily before bed to amplify the natural nocturnal GH pulse. Must be taken fasted (or at least 2 hours after eating) — insulin blunts GH release. Sermorelin is gentler than CJC-1295 and a good starting point for GH peptide beginners. Can be stacked with Ipamorelin or GHRP-2 for enhanced effect.